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DCRL RESEARCH:Ubiquitin-proteasome-system and enzymes of energy metabolism in skeletal muscle of patients with HFpEF and HFrEF

Volker Adams1,2†, Sebastian Wunderlich3†, Norman Mangner1, Jennifer Hommel1, Katrin Esefeld4,5,
Stephan Gielen6, Martin Halle4,5, Øyvind Ellingsen7,8, Emeline M. Van Craenenbroeck9,10, Ulrik Wisløff8,
Burkert Pieske11, Axel Linke1,2 and Ephraim B. Winzer1*
1Department of Internal Medicine and Cardiology, Technische Universität Dresden, Heart Center Dresden – University Hospital, Herzzentrum Dresden, Universitätsklinik,
Fetscherstraße 76, Dresden, 01307, Germany; 2Dresden Cardiovascular Research Institute and Core Laboratories GmbH, Dresden, Germany; 3Department of Internal
Medicine/Cardiology, Heart Center Leipzig – University Hospital, Leipzig, Germany; 4DZHK (German Center for Cardiovascular Research), Partner Site Munich Heart Alliance,
Munich, Germany; 5Department of Prevention and Sports Medicine, Technische Universität München, Klinikum rechts der Isar, Munich, Germany; 6Department of Cardiology,
Angiology and Intensive Care, Klinikum Lippe, Detmold, Germany; 7Department of Cardiology, St. Olavs University Hospital, Trondheim, Norway; 8The Cardiac Exercise
Research Group at Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim, Norway; 9Department of Cardiology,
Antwerp University Hospital, Edegem, Belgium; 10Research Group Cardiovascular Diseases, GENCOR, University of Antwerp, Antwerp, Belgium; and 11Department Internal
Medicine and Cardiology, Campus Virchow Klinikum, Charité Universitätsmedizin Berlin, Berlin, Germany