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DCRL RESEARCH: Small-Molecule Chemical Knockdown of MuRF1 in Melanoma Bearing Mice Attenuates Tumor Cachexia Associated Myopathy

Volker Adams 1,2,*,y, Victoria Gußen 1,y, Sergey Zozulya 3 , André Cruz 4 , Anselmo Moriscot 4,
Axel Linke 1,2 and Siegfried Labeit 5
1 Laboratory of Molecular and Experimental Cardiology, TU Dresden, Heart Center Dresden,
1307 Dresden, Germany; victoria.gussen@gmx.de (V.G.); Axel.linke@tu-dresden.de (A.L.)
2 Dresden Cardiovascular Research Institute and Core Laboratories GmbH, 01067 Dresden, Germany
3 Department of Drug Research, Enamine-Bienta Ltd., 02000 Kiev, Ukraine; s.zozulya@enamine.net
4 Department of Anatomy, Institute of Biomedical Sciences, University of Sao Paulo,
Sao Paulo 05508-000, Brazil; andrecruz@usp.br (A.C.); moriscot@usp.br (A.M.)
5 Medical Faculty Mannheim, University of Heidelberg, 68167 Mannheim, Germany; labeit@medma.de
* Correspondence: volker.adams@mailbox.tu-dresden.de; Tel.: +49-(0)3514586627
y These authors contributed equally to this work.
Received: 4 September 2020; Accepted: 21 September 2020; Published: 11 October 2020